![]() ( 14) reported that patients with more severe nocturnal IH who were untreated showed a significant increased risk in all-cancer incidence independently of all the cancers, lung cancer showed the most statistical significance. Interestingly, it has been claimed that OSA may be positively associated with various malignant neoplasms in humans ( 13). One additional aspect of managing OSA lies in its efficacy in reducing the risk of the development of, for example, ischemic heart disease, stroke, and type 2 diabetes mellitus (DM) with decreased morbidity ( 11, 12). Therefore, OSA acts as an independent predisposing factor for developing various cerebrovascular and metabolic disorders ( 10). Patients with OSA show intermittent hypoxemia (IH) with or without hypercapnia, resulting in functional changes in the autonomous nerve system ( 3– 5), as well as structural or molecular changes in the cardiovascular ( 6), neurologic ( 7), immune ( 8), or endocrine organs ( 9). In South Korea, the prevalence of OSA is reportedly 4.5% in males and 3.2% in females ( 2). ![]() The incidence of obstructive sleep apnea (OSA) is increasing worldwide, affecting approximately 15% of males and 5% of females in the North American population ( 1). The observed significance of this finding was limited to male OSA patients, while no significant association was found in female OSA patients, irrespective of their age.ĭiscussion: OSA patients have a lower risk of developing lung cancer, but this risk reduction is gender-specific, as female OSA patients do not show a reduction in hazard ratio. Results: The hazard ratio (HR) of OSA for lung cancer incidence showed a significantly reduced HR of 0.87 (95% CI, 0.82–0.93). The control group was set with age and sex that matched those in the OSA group. The main outcome measure was newly diagnosed lung cancer. Methods: A retrospective cohort of adult patients newly registered with OSA in the KNHIS data from 2007 to 2017 was included and observed until December 2019 (12 years). By analyzing the Korea National Health Insurance Service (KNHIS) registry, the impact of OSA on the lung cancer incidence was analyzed in a retrospective cohort group. Introduction: Obstructive sleep apnea (OSA) is known to increase the risk of various cancers. 4Department of Otorhinolaryngology-Head and Neck Surgery, Bucheon Hospital, College of Medicine, Soonchunhyang University, Bucheon, Republic of Korea.3Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Konkuk University, Seoul, Republic of Korea.2Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.1Department of Otorhinolaryngology-Head and Neck Surgery, Inha University Hospital, School of Medicine, Inha University, Incheon, Republic of Korea. ![]() Marn Joon Park 1 Kyung-Do Han 2 Jae Hoon Cho 3*† Ji Ho Choi 4*†
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